Could be the purity/strength. Sometimes it takes more time. My brother claims it's not doing anything for him, but he uses the roll on, once.I was at the feed store this AM getting chicken stuff & decided to pop over to the horse meds isle. They had a little bottle of DMSO gel.
After I got home I put some on my knee & foot - after a shift in the creel, both were killing me.
I didn't notice much difference.
I coated them both again this evening before heading in. Still, not a huge difference.
Maybe it's a cumulative effect???